| Tissue Specificity | Highly expressed in intestinal myeloid-derived cells and expressed in monocyte-derived macrophages upon induction by PRR activation. |
| Function | Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion. In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation. |
| Protein Name | Innate Immunity Activator Protein |
| Cellular Localisation | NucleusCytoplasmTranslocates To The Nucleus Upon Nod2 Stimulation |
| Alternative Antibody Names | Anti-Innate Immunity Activator Protein antibodyAnti-INAVA antibodyAnti-C1orf106 antibody |
Information sourced from Uniprot.org
