| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | C1D |
| Gene ID: | 10438 |
| Uniprot ID: | C1D_HUMAN |
| Immunogen Region: | 1-141 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-141 of human C1D (NP_001177194.1). |
| Immunogen Sequence: | MAGEEINEDYPVEIHEYLSA FENSIGAVDEMLKTMMSVSR NELLQKLDPLEQAKVDLVSA YTLNSMFWVYLATQGVNPKE HPVKQELERIRVYMNRVKEI TDKKKAGKLDRGAASRFVKN ALWEPKSKNASKVANKGKSK S |
| Tissue Specificity | Ubiquitous. Expressed at very high levels in the hippocampus, medulla oblongata, mammary gland, thyroid and salivary gland. Expressed at high levels in the fetal.lung, liver and kidney. Expressed at low levels in skeletal muscle, appendix, heart, lung and colon. |
| Post Translational Modifications | Phosphorylated by PRKDC. |
| Function | Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB. |
| Protein Name | Nuclear Nucleic Acid-Binding Protein C1d Hc1d |
| Database Links | Reactome: R-HSA-6791226 |
| Cellular Localisation | Nucleus Cytoplasm Nucleolus Exosc10 Is Required For Nucleolar Localization Colocalizes With Tsnax In The Nucleus |
| Alternative Antibody Names | Anti-Nuclear Nucleic Acid-Binding Protein C1d antibody Anti-Hc1d antibody Anti-C1D antibody |
Information sourced from Uniprot.org