• STJ70304 Immunofluorescence analysis of paraformaldehyde fixed U2OS cells, permeabilized with 0. 15% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml) , showing nuclear staining. Actin filaments were stained with phalloidin (red) and the nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml).

Anti-BS69/ZMYND11 antibody (N-Term) (STJ70304)

SKU:
STJ70304-100

£303.50
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Host: Goat
Applications: Pep-ELISA/IF
Reactivity: Human/Mouse/Rat/Dog/Pig/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-BS69/ZMYND11 (N-Term) is suitable for use in ELISA and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: IF-Strong expression of the protein seen in the nuclei of U2OS cells. 10µg/ml
ELISA-antibody detection limit dilution 1:32000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: ZMYND11
Gene ID: 10771
Uniprot ID: ZMY11_HUMAN
Immunogen Region: N-Term
Accession Number: NP_006615.2; NP_997644.2; NP_001189393.1; NP_001189394.1; NP_001189395.1; NP_001189396.1; NP_001189397.1
Specificity: This antibody is expected to recognise all reported human isoforms (NP_006615.2; NP_997644.2; NP_001189393.1; NP_001189394.1; NP_001189395.1; NP_001189396.1; NP_001189397.1).
Immunogen Sequence: SRVHGMHPKETT
Post Translational Modifications Sumoylated following its interaction with PIAS1 and UBE2I. Ubiquitinated, leading to proteasomal degradation.
Function Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA. Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth. (Microbial infection) Inhibits Epstein-Barr virus EBNA2-mediated transcriptional activation and host cell proliferation, through direct interaction.
Protein Name Zinc Finger Mynd Domain-Containing Protein 11
Adenovirus 5 E1a-Binding Protein
Bone Morphogenetic Protein Receptor-Associated Molecule 1
Protein Bs69
Cellular Localisation Nucleus
Chromosome
Associates With Chromatin And Mitotic Chromosomes
Alternative Antibody Names Anti-Zinc Finger Mynd Domain-Containing Protein 11 antibody
Anti-Adenovirus 5 E1a-Binding Protein antibody
Anti-Bone Morphogenetic Protein Receptor-Associated Molecule 1 antibody
Anti-Protein Bs69 antibody
Anti-ZMYND11 antibody
Anti-BRAM1 antibody
Anti-BS69 antibody

Information sourced from Uniprot.org

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