| Host: | Goat |
| Applications: | Pep-ELISA/IF |
| Reactivity: | Human/Mouse/Rat/Dog/Pig/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-BS69/ZMYND11 (N-Term) is suitable for use in ELISA and Immunofluorescence research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:32000.IF: Strong expression of the protein seen in the nuclei of U2OS cells. Recommended concentration: 10µg/ml. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | ZMYND11 |
| Gene ID: | 10771 |
| Uniprot ID: | ZMY11_HUMAN |
| Immunogen Region: | N-Term |
| Accession Number: | NP_006615.2; NP_997644.2; NP_001189393.1; NP_001189394.1; NP_001189395.1; NP_001189396.1; NP_001189397.1 |
| Specificity: | This antibody is expected to recognise all reported human isoforms (NP_006615.2; NP_997644.2; NP_001189393.1; NP_001189394.1; NP_001189395.1; NP_001189396.1; NP_001189397.1). |
| Immunogen Sequence: | SRVHGMHPKETT |
| Post Translational Modifications | Sumoylated following its interaction with PIAS1 and UBE2I. Ubiquitinated, leading to proteasomal degradation. |
| Function | Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA. Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth. (Microbial infection) Inhibits Epstein-Barr virus EBNA2-mediated transcriptional activation and host cell proliferation, through direct interaction. |
| Protein Name | Zinc Finger Mynd Domain-Containing Protein 11Adenovirus 5 E1a-Binding ProteinBone Morphogenetic Protein Receptor-Associated Molecule 1Protein Bs69 |
| Cellular Localisation | NucleusChromosomeAssociates With Chromatin And Mitotic Chromosomes |
| Alternative Antibody Names | Anti-Zinc Finger Mynd Domain-Containing Protein 11 antibodyAnti-Adenovirus 5 E1a-Binding Protein antibodyAnti-Bone Morphogenetic Protein Receptor-Associated Molecule 1 antibodyAnti-Protein Bs69 antibodyAnti-ZMYND11 antibodyAnti-BRAM1 antibodyAnti-BS69 antibody |
Information sourced from Uniprot.org
