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| Host: | Alpaca |
| Applications: | ELISA/SPR |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Alpaca monoclonal nanobody anti-Recq-Like Dna Helicase Blm is suitable for use in ELISA and SPR research applications. |
| Clonality : | Monoclonal |
| Clone ID : | SAA1186 |
| Conjugation: | Unconjugated |
| Isotype: | VHH-8His-Cys-tag |
| Formulation: | 0.01M PBS, pH 7.4. |
| Purification: | Purified by Nickel column. |
| Concentration: | 1 mg/mL |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
| Function | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction. Participates in DNA replication and repair. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution. Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA. Unwinds G-quadruplex DNA.unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides. Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates. Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich.formation of G-quadruplex DNA would block DNA replication and transcription. Negatively regulates sister chromatid exchange (SCE). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks. (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. |
| Protein Name | Recq-Like Dna Helicase BlmBloom Syndrome ProteinDna 3'-5' Helicase BlmDna Helicase - Recq-Like Type 2Recq2Recq Protein-Like 3 |
| Database Links | Reactome: R-HSA-174414Reactome: R-HSA-3108214Reactome: R-HSA-5685938Reactome: R-HSA-5685942Reactome: R-HSA-5693554Reactome: R-HSA-5693568Reactome: R-HSA-5693579Reactome: R-HSA-5693607Reactome: R-HSA-5693616Reactome: R-HSA-6804756Reactome: R-HSA-69473Reactome: R-HSA-912446Reactome: R-HSA-9701192Reactome: R-HSA-9704331Reactome: R-HSA-9704646Reactome: R-HSA-9709570Reactome: R-HSA-9709603 |
| Cellular Localisation | NucleusTogether With SpidrIs Redistributed In Discrete Nuclear Dna Damage-Induced Foci Following Hydroxyurea (Hu) Or Camptothecin (Cpt) TreatmentAccumulated At Sites Of Dna Damage In A Rmi Complex- And Spidr-Dependent Manner |
| Alternative Nanobody Names | Anti-Recq-Like Dna Helicase Blm nanobodyAnti-Bloom Syndrome Protein nanobodyAnti-Dna 3'-5' Helicase Blm nanobodyAnti-Dna Helicase - Recq-Like Type 2 nanobodyAnti-Recq2 nanobodyAnti-Recq Protein-Like 3 nanobodyAnti-BLM nanobodyAnti-RECQ2 nanobodyAnti-RECQL3 nanobody |
Information sourced from Uniprot.org
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