| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-BCL11A (1-230) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BCL11A |
| Gene ID: |
53335 |
| Uniprot ID: |
BC11A_HUMAN |
| Immunogen Region: |
1-230 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human CTIP1/CTIP1/BCL11A (NP_060484.2). |
| Immunogen Sequence: |
MSRRKQGKPQHLSKREFSPE PLEAILTDDEPDHGPLGAPE GDHDLLTCGQCQMNFPLGDI LIFIEHKRKQCNGSLCLEKA VDKPPSPSPIEMKKASNPVE VGIQVTPEDDDCLSTSSRGI CPKQEHIADKLLHWRGLSSP RSAHGALIPTPGMSAEYAPQ GICKDEPSSYTCTTCKQPFT SAWFLLQHAQNTHGLRIYLE SEHGSPLTPRVGIPSGLGAE CPSQPPLHGI |
| Tissue Specificity | Expressed at high levels in brain, spleen thymus, bone marrow and testis. Expressed in CD34-positive myeloid precursor cells, B-cells, monocytes and megakaryocytes. Expression is tightly regulated during B-cell development. Isoform 1: Expressed in fetal and adult brain, and in the plasmacytoid dendritic cell. |
| Post Translational Modifications | Sumoylated with SUMO1. |
| Function | Transcription factor. Associated with the BAF SWI/SNF chromatin remodeling complex. Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene. Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1.hence indirectly repressing fetal hemoglobin (HbF) level. Involved in brain development. May play a role in hematopoiesis. Essential factor in lymphopoiesis required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of NR2F2. |
| Protein Name | B-Cell Lymphoma/Leukemia 11aBcl-11aB-Cell Cll/Lymphoma 11aCoup-Tf-Interacting Protein 1Ecotropic Viral Integration Site 9 Protein HomologEvi-9Zinc Finger Protein 856 |
| Database Links | Reactome: R-HSA-9700645Reactome: R-HSA-9725370 |
| Cellular Localisation | CytoplasmNucleusChromosomeAssociates With The Nuclear BodyColocalizes With Sumo1 And Senp2 In Nuclear SpecklesIsoform 1: Nucleus MatrixColocalizes With Bcl6 In Nuclear ParaspecklesIsoform 2: CytoplasmPredominantly Localized In The Nucleus In Nuclear ParaspecklesIsoform 3: CytoplasmPredominantly Localized In The Cytoplasm In The Absence Of Interaction With Isoform 1 And Isoform 2In Presence Of Isoform 1 Or Isoform 2Translocates From The Cytoplasm Into Nuclear Paraspeckles |
| Alternative Antibody Names | Anti-B-Cell Lymphoma/Leukemia 11a antibodyAnti-Bcl-11a antibodyAnti-B-Cell Cll/Lymphoma 11a antibodyAnti-Coup-Tf-Interacting Protein 1 antibodyAnti-Ecotropic Viral Integration Site 9 Protein Homolog antibodyAnti-Evi-9 antibodyAnti-Zinc Finger Protein 856 antibodyAnti-BCL11A antibodyAnti-CTIP1 antibodyAnti-EVI9 antibodyAnti-KIAA1809 antibodyAnti-ZNF856 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
