| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-BBS5 (1-341) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BBS5 |
| Gene ID: |
129880 |
| Uniprot ID: |
BBS5_HUMAN |
| Immunogen Region: |
1-341 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-341 of human BBS5 (NP_689597.1). |
| Immunogen Sequence: |
MSVLDALWEDRDVRFDLSAQ QMKTRPGEVLIDCLDSIEDT KGNNGDRGRLLVTNLRILWH SLALSRVNVSVGYNCILNIT TRTANSKLRGQTEALYILTK CNSTRFEFIFTNLVPGSPRL FTSVMAVHRAYETSKMYRDF KLRSALIQNKQLRLLPQEHV YDKINGVWNLSSDQGNLGTF FITNVRIVWHANMNDSFNVS IPYLQIRSIKIRDSKFGLAL VIESSQQSGGYVLGFKIDP |
| Function | The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly. |
| Protein Name | Bardet-Biedl Syndrome 5 Protein |
| Database Links | Reactome: R-HSA-5620922 |
| Cellular Localisation | Cell ProjectionCilium MembraneCytoplasmCytoskeletonCilium Basal BodyMicrotubule Organizing CenterCentrosomeCentriolar SatelliteLocalizes To Basal Bodies |
| Alternative Antibody Names | Anti-Bardet-Biedl Syndrome 5 Protein antibodyAnti-BBS5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
