| Host: | Rabbit |
| Applications: | IF/ICC/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | SRM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IF/ICC:1:100-1:400 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | TNFSF13B |
| Gene ID: | 10673 |
| Uniprot ID: | TN13B_HUMAN |
| Immunogen Region: | 134-285 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 134-285 of human BAFF/BLyS/CD257 (NP_006564.1). |
| Immunogen Sequence: | AVQGPEETVTQDCLQLIADS ETPTIQKGSYTFVPWLLSFK RGSALEEKENKILVKETGYF FIYGQVLYTDKTYAMGHLIQ RKKVHVFGDELSLVTLFRCI QNMPETLPNNSCYSAGIAKL EEGDELQLAIPRENAQISLD GDVTFFGALKLL |
| Tissue Specificity | Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T-cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. Isoform 2 is expressed in many myeloid cell lines. |
| Post Translational Modifications | The soluble form derives from the membrane form by proteolytic processing. Isoform 2 is not efficiently shed from the membrane unlike isoform 1. N-glycosylated. |
| Function | Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis. |
| Protein Name | Tumor Necrosis Factor Ligand Superfamily Member 13b B Lymphocyte Stimulator Blys B-Cell-Activating Factor Baff Dendritic Cell-Derived Tnf-Like Molecule Tnf- And Apol-Related Leukocyte Expressed Ligand 1 Tall-1 Cd Antigen Cd257 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 13b - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 13b - Soluble Form |
| Database Links | Reactome: R-HSA-5668541 Reactome: R-HSA-5669034 Reactome: R-HSA-5676594 |
| Cellular Localisation | Cell Membrane Single-Pass Type Ii Membrane Protein Tumor Necrosis Factor Ligand Superfamily Member 13b Soluble Form: Secreted |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Ligand Superfamily Member 13b antibody Anti-B Lymphocyte Stimulator antibody Anti-Blys antibody Anti-B-Cell-Activating Factor antibody Anti-Baff antibody Anti-Dendritic Cell-Derived Tnf-Like Molecule antibody Anti-Tnf- And Apol-Related Leukocyte Expressed Ligand 1 antibody Anti-Tall-1 antibody Anti-Cd Antigen Cd257 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 13b - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 13b - Soluble Form antibody Anti-TNFSF13B antibody Anti-BAFF antibody Anti-BLYS antibody Anti-TALL1 antibody Anti-TNFSF20 antibody Anti-ZTNF4 antibody Anti-UNQ401 antibody Anti-PRO738 antibody |
Information sourced from Uniprot.org