| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-AZIN1 (289-448) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
AZIN1 |
| Gene ID: |
51582 |
| Uniprot ID: |
AZIN1_HUMAN |
| Immunogen Region: |
289-448 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 289-448 of human AZIN1 (NP_056962.2). |
| Immunogen Sequence: |
AKKVVENDKFPSGVEKTGSD EPAFMYYMNDGVYGSFASKL SEDLNTIPEVHKKYKEDEPL FTSSLWGPSCDELDQIVESC LLPELNVGDWLIFDNMGADS FHEPSAFNDFQRPAIYYMMS FSDWYEMQDAGITSDSMMKN FFFVPSCIQLSQEDSFSAEA |
| Tissue Specificity | Expressed in liver. |
| Post Translational Modifications | Ubiquitinated, leading to its proteasomal degradation.a process that is reduced in presence of antizyme OAZ1. |
| Function | Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production. |
| Protein Name | Antizyme Inhibitor 1AziAzi1Ornithine Decarboxylase Antizyme Inhibitor |
| Database Links | Reactome: R-HSA-350562 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Antizyme Inhibitor 1 antibodyAnti-Azi antibodyAnti-Azi1 antibodyAnti-Ornithine Decarboxylase Antizyme Inhibitor antibodyAnti-AZIN1 antibodyAnti-OAZI antibodyAnti-OAZIN antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
