| Post Translational Modifications | Proteolytically cleaved by caspase-7 (CASP7). The cleavage may be involved in SCA7 degeneration: the isoform fragments may exert distinct toxic influences that could contribute to selective neurodegeneration. Sumoylation decreases the aggregation propensity and cellular toxicity of forms with an expanded poly-Gln region but has no effect on subcellular location or interaction with components of the STAGA complex. |
| Function | Acts as a component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary for microtubule cytoskeleton stabilization. |
| Protein Name | Ataxin-7Spinocerebellar Ataxia Type 7 Protein |
| Database Links | Reactome: R-HSA-3214847Reactome: R-HSA-5689880 |
| Cellular Localisation | Isoform A: NucleusNucleusNucleolusNucleus MatrixCytoplasmCytoskeletonIn Addition To A Diffuse Distribution Throughout The NucleusIt Is Associated With The Nuclear Matrix And The NucleolusIt Is Able To Shuttle Between The Nucleus And CytoplasmIsoform B: Cytoplasm |
| Alternative Antibody Names | Anti-Ataxin-7 antibodyAnti-Spinocerebellar Ataxia Type 7 Protein antibodyAnti-ATXN7 antibodyAnti-SCA7 antibody |
Information sourced from Uniprot.org
