| Tissue Specificity | Found in most adult tissues except liver, testis and placenta. Most abundant in heart, brain and skeletal muscle. Also detected in fetal tissues. Isoform 1 is only detected in brain, skeletal muscle and heart and is the most abundant form in skeletal muscle. Highly expressed in platelets. |
| Post Translational Modifications | Cleaved by calpain in a caspase- and calcium influx-dependent manner during platelet apoptosis leading to a 100 kDa polypeptide. |
| Function | Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the cell membrane. Acts as aminophospholipid translocase at the cell membrane in neuronal cells. |
| Protein Name | Phospholipid-Transporting Atpase IaAtpase Class I Type 8a Member 1Chromaffin Granule Atpase IiP4-Atpase Flippase Complex Alpha Subunit Atp8a1 |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-936837 |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleChromaffin Granule MembraneMulti-Pass Membrane ProteinCytoplasmic GranuleCell MembraneEndoplasmic ReticulumGolgi ApparatusExit From The Endoplasmic Reticulum Requires The Presence Of Tmem30aBut Not Tmem30bIn The Presence Of Tmem30aPredominantly Located In Cytoplasmic Punctate Structures And Localizes To The Cell MembraneLocalizes To Plasma Membranes Of Red Blood Cells |
| Alternative Antibody Names | Anti-Phospholipid-Transporting Atpase Ia antibodyAnti-Atpase Class I Type 8a Member 1 antibodyAnti-Chromaffin Granule Atpase Ii antibodyAnti-P4-Atpase Flippase Complex Alpha Subunit Atp8a1 antibodyAnti-ATP8A1 antibodyAnti-ATPIA antibody |
Information sourced from Uniprot.org
