| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Swine |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-V-type proton ATPase catalytic subunit A is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ATP6V1A |
| Gene ID: | 523 |
| Uniprot ID: | VATA_HUMAN |
| Specificity: | VATA Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from part of the human protein |
| Post Translational Modifications | Phosphorylation at Ser-384 by AMPK down-regulates its enzyme activity. |
| Function | Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in neurite development and synaptic connectivity. (Microbial infection) Plays an important role in virion uncoating during Rabies virus replication after membrane fusion. Specifically, participates in the dissociation of incoming viral matrix M proteins uncoating through direct interaction. |
| Protein Name | V-Type Proton Atpase Catalytic Subunit A V-Atpase Subunit A V-Atpase 69 Kda Subunit Vacuolar Atpase Isoform Va68 Vacuolar Proton Pump Subunit Alpha |
| Database Links | Reactome: R-HSA-1222556 Reactome: R-HSA-77387 Reactome: R-HSA-917977 Reactome: R-HSA-9639288 Reactome: R-HSA-983712 Reactome: R-HSA-9857377 |
| Cellular Localisation | Cytoplasm Cytosol Cytoplasmic Vesicle Secretory Vesicle Clathrin-Coated Vesicle Membrane Peripheral Membrane Protein Lysosome Co-Localizes With Wfs1 In The Secretory Granules In Neuroblastoma Cell Lines |
| Alternative Antibody Names | Anti-V-Type Proton Atpase Catalytic Subunit A antibody Anti-V-Atpase Subunit A antibody Anti-V-Atpase 69 Kda Subunit antibody Anti-Vacuolar Atpase Isoform Va68 antibody Anti-Vacuolar Proton Pump Subunit Alpha antibody Anti-ATP6V1A antibody Anti-ATP6A1 antibody Anti-ATP6V1A1 antibody Anti-VPP2 antibody |
Information sourced from Uniprot.org