| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ARRDC4 |
| Gene ID: | 91947 |
| Uniprot ID: | ARRD4_HUMAN |
| Immunogen Region: | 300-400 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 300-400 of human ARRDC4 (NP_899232.2). |
| Immunogen Sequence: | PGAKKLMLELPLVIGTIPYN GFGSRNSSIASQFSMDMSWL TLTLPEQPEAPPNYADVVSE EEFSRHIPPYPQPPNCEGEV CCPVFACIQEFRFQPPPLYS E |
| Function | Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates. Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) (Probable). Through an ubiquitination-dependent mechanism also plays a role in the incorporation of SLC11A2 into extracellular vesicles. May play a role in glucose uptake. Participates in innate immune response by promoting IFIH1/MDA5 activation through interaction with TRIM65. |
| Protein Name | Arrestin Domain-Containing Protein 4 |
| Cellular Localisation | Early EndosomeCell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmic VesicleAlso Found In Extracellular Vesicles Different From Exosomes |
| Alternative Antibody Names | Anti-Arrestin Domain-Containing Protein 4 antibodyAnti-ARRDC4 antibody |
Information sourced from Uniprot.org