| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
ARPC1B |
| Gene ID: |
10095 |
| Uniprot ID: |
ARC1B_HUMAN |
| Immunogen Region: |
10-80 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 10-80 of human ARPC1B (NP_005711.1). |
| Immunogen Sequence: |
PISCHAWNKDRTQIAICPNN HEVHIYEKSGAKWTKVHELK EHNGQVTGIDWAPESNRIVT CGTDRNAYVWT |
| Function | Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). |
| Protein Name | Actin-Related Protein 2/3 Complex Subunit 1bArp2/3 Complex 41 Kda SubunitP41-Arc |
| Database Links | Reactome: R-HSA-2029482Reactome: R-HSA-3928662Reactome: R-HSA-5663213Reactome: R-HSA-9664422 |
| Cellular Localisation | CytoplasmCytoskeletonNucleus |
| Alternative Antibody Names | Anti-Actin-Related Protein 2/3 Complex Subunit 1b antibodyAnti-Arp2/3 Complex 41 Kda Subunit antibodyAnti-P41-Arc antibodyAnti-ARPC1B antibodyAnti-ARC41 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
