Anti-ARG1 antibody (1-322) (STJ26182)

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STJ26182
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Host: Rabbit
Applications: WB/IF/ICC/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:1000
IF/ICC:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ARG1
Gene ID: 383
Uniprot ID: ARGI1_HUMAN
Immunogen Region: 1-322
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-322 of human Arginase 1 (ARG1) (NP_000036.2).
Immunogen Sequence: MSAKSRTIGIIGAPFSKGQP RGGVEEGPTVLRKAGLLEKL KEQECDVKDYGDLPFADIPN DSPFQIVKNPRSVGKASEQL AGKVAEVKKNGRISLVLGGD HSLAIGSISGHARVHPDLGV IWVDAHTDINTPLTTTSGNL HGQPVSFLLKELKGKIPDVP GFSWVTPCISAKDIVYIGLR DVDPGEHYILKTLGIKYFSM TEVDRLGIGKVMEETLSYLL GRKKRPIHLSFDVDGLDPS
Tissue Specificity Within the immune system initially reported to be selectively expressed in granulocytes (polymorphonuclear leukocytes PMNs). Also detected in macrophages mycobacterial granulomas. Expressed in group2 innate lymphoid cells (ILC2s) during lung disease.
Function Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively.the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available intracellular substrate arginine. Arginine metabolism is a critical regulator of innate and adaptive immune responses. Involved in an antimicrobial effector pathway in polymorphonuclear granulocytes (PMN). Upon PMN cell death is liberated from the phagolysosome and depletes arginine in the microenvironment leading to suppressed T cell and natural killer (NK) cell proliferation and cytokine secretion. In group 2 innate lymphoid cells (ILC2s) promotes acute type 2 inflammation in the lung and is involved in optimal ILC2 proliferation but not survival. In humans, the immunological role in the monocytic/macrophage/dendritic cell (DC) lineage is unsure.
Protein Name Arginase-1
Liver-Type Arginase
Type I Arginase
Database Links Reactome: R-HSA-6798695
Reactome: R-HSA-70635
Cellular Localisation Cytoplasm
Cytoplasmic Granule
Localized In Azurophil Granules Of Neutrophils
Alternative Antibody Names Anti-Arginase-1 antibody
Anti-Liver-Type Arginase antibody
Anti-Type I Arginase antibody
Anti-ARG1 antibody

Information sourced from Uniprot.org