| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-AMICA1 (285-384) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
JAML |
| Gene ID: |
120425 |
| Uniprot ID: |
JAML_HUMAN |
| Immunogen Region: |
285-384 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 285-384 of human AMICA1 (NP_694938.2). |
| Immunogen Sequence: |
IVKKTCGNKSSVNSTVLVKN TKKTNPEIKEKPCHFERCEG EKHIYSPIIVREVIEEEEPS EKSEATYMTMHPVWPSLRSD RNNSLEKKSGGGMPKTQQAF |
| Tissue Specificity | Expression is restricted to the hematopoietic tissues with the exception of liver. Expressed in fetal liver, spleen and thymus. Preferentially expressed by mature leukocytes (at protein level). |
| Function | Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR. |
| Protein Name | Junctional Adhesion Molecule-LikeAdhesion Molecule Interacting With Cxadr Antigen 1Dendritic Cell-Specific Protein Crea7-1 |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-202733 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionLocalized At The Plasma Membrane And Enriched In Areas Of Cell-Cell Contacts |
| Alternative Antibody Names | Anti-Junctional Adhesion Molecule-Like antibodyAnti-Adhesion Molecule Interacting With Cxadr Antigen 1 antibodyAnti-Dendritic Cell-Specific Protein Crea7-1 antibodyAnti-JAML antibodyAnti-AMICA1 antibodyAnti-UNQ722 antibodyAnti-PRO1387 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
