| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ALDH3B1 |
| Gene ID: |
221 |
| Uniprot ID: |
AL3B1_HUMAN |
| Immunogen Region: |
1-80 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human ALDH3B1 (NP_001025181.1). |
| Immunogen Sequence: |
MDPLGDTLRRLREAFHAGRT RPAEFRAAQLQGLGRFLQEN KQLLHDALAQDLHKATQLDS AFIRKEPFGLVLIIAPWNYP |
| Tissue Specificity | Highest expression in kidney and lung. |
| Post Translational Modifications | Dually lipidated in the C-terminus.prenylation occurs prior to, and is a prerequisite for palmitoylation. It is also required for activity towards long-chain substrates. |
| Function | Oxidizes medium and long chain saturated and unsaturated fatty aldehydes generated in the plasma membrane into non-toxic fatty acids. May have a protective role against the cytotoxicity induced by lipid peroxidation. Short-chain fatty aldehydes are not good substrates. Can use both NADP(+) and NAD(+) as electron acceptor in vitro, however in vivo preference will depend on their tissue levels. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. Able to metabolize aromatic aldehydes such as benzaldehyde to their acid form. |
| Protein Name | Aldehyde Dehydrogenase Family 3 Member B1 Aldehyde Dehydrogenase 7Long-Chain Fatty Aldehyde DehydrogenaseMedium-Chain Fatty Aldehyde Dehydrogenase |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-9845614 |
| Cellular Localisation | Cell MembraneLipid-AnchorPrimarily In The Plasma Membrane As Well As In Some Punctate Structures In The Cytoplasm |
| Alternative Antibody Names | Anti-Aldehyde Dehydrogenase Family 3 Member B1 antibodyAnti-Aldehyde Dehydrogenase 7 antibodyAnti-Long-Chain Fatty Aldehyde Dehydrogenase antibodyAnti-Medium-Chain Fatty Aldehyde Dehydrogenase antibodyAnti-ALDH3B1 antibodyAnti-ALDH7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
