| Tissue Specificity | Highest expression in kidney and lung. |
| Post Translational Modifications | Dually lipidated in the C-terminus.prenylation occurs prior to, and is a prerequisite for palmitoylation. It is also required for activity towards long-chain substrates. |
| Function | Oxidizes medium and long chain saturated and unsaturated fatty aldehydes generated in the plasma membrane into non-toxic fatty acids. May have a protective role against the cytotoxicity induced by lipid peroxidation. Short-chain fatty aldehydes are not good substrates. Can use both NADP(+) and NAD(+) as electron acceptor in vitro, however in vivo preference will depend on their tissue levels. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. Able to metabolize aromatic aldehydes such as benzaldehyde to their acid form. |
| Protein Name | Aldehyde Dehydrogenase Family 3 Member B1 Aldehyde Dehydrogenase 7Long-Chain Fatty Aldehyde DehydrogenaseMedium-Chain Fatty Aldehyde Dehydrogenase |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-9845614 |
| Cellular Localisation | Cell MembraneLipid-AnchorPrimarily In The Plasma Membrane As Well As In Some Punctate Structures In The Cytoplasm |
| Alternative Antibody Names | Anti-Aldehyde Dehydrogenase Family 3 Member B1 antibodyAnti-Aldehyde Dehydrogenase 7 antibodyAnti-Long-Chain Fatty Aldehyde Dehydrogenase antibodyAnti-Medium-Chain Fatty Aldehyde Dehydrogenase antibodyAnti-ALDH3B1 antibodyAnti-ALDH7 antibody |
Information sourced from Uniprot.org
