Immunofluorescence analysis of A549 cells, using ADRA1A Antibody. The picture on the right is blocked with the synthesized peptide.

Anti-ADRA1A antibody (136-185 aa) (STJ91719)

SKU:
STJ91719
£48.00 - £252.00
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Host: Rabbit
Applications: WB/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Alpha-1A adrenergic receptor (136-185 aa) is suitable for use in Western Blot, Immunofluorescence and ELISA research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IF 1:200-1:1000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ADRA1A
Gene ID: 148
Uniprot ID: ADA1A_HUMAN
Immunogen Region: 136-185 aa
Specificity: AR-Alpha 1A Polyclonal Antibody detects endogenous levels of AR-Alpha 1A protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human ADRA1A at the amino acid range 136-185
Post Translational Modifications C-terminal Ser or Thr residues may be phosphorylated.
Function This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
Protein Name Alpha-1a Adrenergic Receptor
Alpha-1a Adrenoreceptor
Alpha-1a Adrenoceptor
Alpha-1c Adrenergic Receptor
Alpha-Adrenergic Receptor 1c
Database Links Reactome: R-HSA-390696
Reactome: R-HSA-416476
Reactome: R-HSA-416482
Cellular Localisation Nucleus Membrane
Multi-Pass Membrane Protein
Cell Membrane
Cytoplasm
Membrane
Caveola
Location At The Nuclear Membrane Facilitates Heterooligomerization And Regulates Erk-Mediated Signaling In Cardiac Myocytes
Colocalizes With Gnaq
Plcb1 As Well As Lap2 At The Nuclear Membrane Of Cardiac Myocytes
Alternative Antibody Names Anti-Alpha-1a Adrenergic Receptor antibody
Anti-Alpha-1a Adrenoreceptor antibody
Anti-Alpha-1a Adrenoceptor antibody
Anti-Alpha-1c Adrenergic Receptor antibody
Anti-Alpha-Adrenergic Receptor 1c antibody
Anti-ADRA1A antibody
Anti-ADRA1C antibody

Information sourced from Uniprot.org

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