| Function | ADP-ribosylhydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine and threonine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose. Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Does not hydrolyze ADP-ribosyl-arginine, -cysteine, -diphthamide, or -asparagine bonds. Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos. Also hydrolyzes free poly(ADP-ribose) in mitochondria. Specifically digests O-acetyl-ADP-D-ribose, a product of deacetylation reactions catalyzed by sirtuins. Specifically degrades 1''-O-acetyl-ADP-D-ribose isomer, rather than 2''-O-acetyl-ADP-D-ribose or 3''-O-acetyl-ADP-D-ribose isomers. |
| Protein Name | Adp-Ribosylhydrolase Arh3Adp-Ribose Glycohydrolase Arh3Adp-Ribosylhydrolase 3O-Acetyl-Adp-Ribose Deacetylase Arh3Poly(Adp-Ribose Glycohydrolase Arh3Protein Adp-Ribosylarginine Hydrolase-Like Protein 2Protein Adp-Ribosylserine Hydrolase |
| Database Links | Reactome: R-HSA-110362 |
| Cellular Localisation | NucleusCytoplasmChromosomeMitochondrion MatrixRecruited To Dna Lesion Regions Following Dna DamageAdp-D-Ribose-Recognition Is Required For Recruitment To Dna Damage Sites |
| Alternative Antibody Names | Anti-Adp-Ribosylhydrolase Arh3 antibodyAnti-Adp-Ribose Glycohydrolase Arh3 antibodyAnti-Adp-Ribosylhydrolase 3 antibodyAnti-O-Acetyl-Adp-Ribose Deacetylase Arh3 antibodyAnti-Poly(Adp-Ribose Glycohydrolase Arh3 antibodyAnti-Protein Adp-Ribosylarginine Hydrolase-Like Protein 2 antibodyAnti-Protein Adp-Ribosylserine Hydrolase antibodyAnti-ADPRS antibodyAnti-ADPRHL2 antibodyAnti-ARH3 antibody |
Information sourced from Uniprot.org
