| Host: | Rabbit |
| Applications: | WB/IF/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Adhesion G-protein coupled receptor G6 (1091-1140 aa) is suitable for use in Western Blot, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IF 1:200-1:1000 ELISA 1:20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ADGRG6 |
| Gene ID: | 57211 |
| Uniprot ID: | AGRG6_HUMAN |
| Immunogen Region: | 1091-1140 aa |
| Specificity: | DREG Polyclonal Antibody detects endogenous levels of DREG protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human GPR126 at the amino acid range 1091-1140 |
| Post Translational Modifications | Highly glycosylated. Proteolytically cleaved into 2 conserved sites: one in the GPS region of the GAIN-B domain (S1 site) and the other in the middle of the extracellular domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. Furin is involved in the cleavage of the S2 site generating a soluble fragment. Processing at the GPS region occurred independent of and probably prior to the cleavage at the S2 site. Proteolytic cleavage is required for activation of the receptor. |
| Function | G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Couples to G(i)-proteins as well as G(s)-proteins. Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Regulates neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling. May act as a receptor for PRNP which may promote myelin homeostasis. |
| Protein Name | Adhesion G-Protein Coupled Receptor G6 Developmentally Regulated G-Protein-Coupled Receptor G-Protein Coupled Receptor 126 Vascular Inducible G Protein-Coupled Receptor Cleaved Into - Adgrg6 N-Terminal Fragment Adgrg6-Ntf - Adgrg6 C-Terminal Fragment Adgrg6-Ctf |
| Database Links | Reactome: R-HSA-9619665 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Detected On The Cell Surface Of Activated But Not Resting Umbilical Vein |
| Alternative Antibody Names | Anti-Adhesion G-Protein Coupled Receptor G6 antibody Anti-Developmentally Regulated G-Protein-Coupled Receptor antibody Anti-G-Protein Coupled Receptor 126 antibody Anti-Vascular Inducible G Protein-Coupled Receptor Cleaved Into - Adgrg6 N-Terminal Fragment antibody Anti-Adgrg6-Ntf - Adgrg6 C-Terminal Fragment antibody Anti-Adgrg6-Ctf antibody Anti-ADGRG6 antibody Anti-DREG antibody Anti-GPR126 antibody Anti-VIGR antibody |
Information sourced from Uniprot.org