| Post Translational Modifications | Highly glycosylated. Proteolytically cleaved into 2 conserved sites: one in the GPS region of the GAIN-B domain (S1 site) and the other in the middle of the extracellular domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. Furin is involved in the cleavage of the S2 site generating a soluble fragment. Processing at the GPS region occurred independent of and probably prior to the cleavage at the S2 site. Proteolytic cleavage is required for activation of the receptor. |
| Function | G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Couples to G(i)-proteins as well as G(s)-proteins. Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Regulates neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling. May act as a receptor for PRNP which may promote myelin homeostasis. |
| Protein Name | Adhesion G-Protein Coupled Receptor G6Developmentally Regulated G-Protein-Coupled ReceptorG-Protein Coupled Receptor 126Vascular Inducible G Protein-Coupled Receptor Cleaved Into - Adgrg6 N-Terminal FragmentAdgrg6-Ntf - Adgrg6 C-Terminal FragmentAdgrg6-Ctf |
| Database Links | Reactome: R-HSA-9619665 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinDetected On The Cell Surface Of Activated But Not Resting Umbilical Vein |
| Alternative Antibody Names | Anti-Adhesion G-Protein Coupled Receptor G6 antibodyAnti-Developmentally Regulated G-Protein-Coupled Receptor antibodyAnti-G-Protein Coupled Receptor 126 antibodyAnti-Vascular Inducible G Protein-Coupled Receptor Cleaved Into - Adgrg6 N-Terminal Fragment antibodyAnti-Adgrg6-Ntf - Adgrg6 C-Terminal Fragment antibodyAnti-Adgrg6-Ctf antibodyAnti-ADGRG6 antibodyAnti-DREG antibodyAnti-GPR126 antibodyAnti-VIGR antibody |
Information sourced from Uniprot.org
