| Host: |
Rabbit |
| Applications: |
WB/IHC/ICC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Adenylate Cyclase III is suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
100 ul in PBS + 50% Glycerol and 5 mm Sodium Azide |
| Purification: |
This antibody was antigen affinity purified from serum. |
| Dilution Range: |
WB 1:2000IHC 1:10, 000ICC 1:500-1:10, 000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Adcy3 |
| Gene ID: |
64508 |
| Uniprot ID: |
ADCY3_RAT |
| Immunogen: |
Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH. |
| Tissue Specificity | Detected on cilia on the olfactory epithelium (at protein level). Detected on cilia on the olfactory epithelium. |
| Post Translational Modifications | N-glycosylated. Sumoylated. Sumoylation is required for targeting ot olfactory cilia. Rapidly phosphorylated after stimulation by odorants or forskolin. Phosphorylation by CaMK2 at Ser-1076 down-regulates enzyme activity. |
| Function | Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis: specifically activated by G alpha protein GNAL/G(olf) in olfactory epithelium. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet. |
| Protein Name | Adenylate Cyclase Type 3Atp Pyrophosphate-Lyase 3Adenylate Cyclase Type IiiAc-IiiAdenylate Cyclase - Olfactive TypeAdenylyl Cyclase 3Ac3 |
| Database Links | Reactome: R-RNO-163615Reactome: -RNO-170660Reactome: -RNO-170670Reactome: -RNO-418597Reactome: -RNO-5610787 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinGolgi ApparatusCell ProjectionCiliumCytoplasm |
| Alternative Antibody Names | Anti-Adenylate Cyclase Type 3 antibodyAnti-Atp Pyrophosphate-Lyase 3 antibodyAnti-Adenylate Cyclase Type Iii antibodyAnti-Ac-Iii antibodyAnti-Adenylate Cyclase - Olfactive Type antibodyAnti-Adenylyl Cyclase 3 antibodyAnti-Ac3 antibodyAnti-Adcy3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
