• Immunofluorescence of a section of rat hippocampus selectively labeling the neuronal cilia with anti-adenylate cyclase III (STJA0003569, 1:10,000, red) , labeling nuclei with anti-MECP2 (STJA0003679, 1:1000, green) , and Hoechst staining of nuclear DNA.
  • Immunostaining of cultured rat neurons and glia showing strong staining of neuronal cilia using our anti-adenylate cyclase III antibody (STJA0003569, 1:500, red) and axonal and dendritic staining of alpha II spectrin (STJA0003570, 1:500, green) revealing the submembranous cytoskeleton and DNA (blue).
  • Western blot of rat cortical lysate showing specific immunolabeling of the ~160 kDa adenylate cyclase III protein.

Anti-ADCY3 antibody (STJA0003569)

SKU:
STJA0003569-100

£442.50
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Host: Rabbit
Applications: WB/IHC/ICC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Adenylate Cyclase III is suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 100 ul in PBS + 50% Glycerol and 5 mm Sodium Azide
Purification: This antibody was antigen affinity purified from serum.
Dilution Range: WB 1:2000
IHC 1:10, 000
ICC 1:500-1:10, 000
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Adcy3
Gene ID: 64508
Uniprot ID: ADCY3_RAT
Immunogen: Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH.
Tissue Specificity Detected on cilia on the olfactory epithelium (at protein level). Detected on cilia on the olfactory epithelium.
Post Translational Modifications N-glycosylated. Sumoylated. Sumoylation is required for targeting ot olfactory cilia. Rapidly phosphorylated after stimulation by odorants or forskolin. Phosphorylation by CaMK2 at Ser-1076 down-regulates enzyme activity.
Function Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet.
Protein Name Adenylate Cyclase Type 3
Atp Pyrophosphate-Lyase 3
Adenylate Cyclase Type Iii
Ac-Iii
Adenylate Cyclase - Olfactive Type
Adenylyl Cyclase 3
Ac3
Database Links Reactome: R-RNO-163615
Reactome: -RNO-170660
Reactome: -RNO-170670
Reactome: -RNO-418597
Reactome: -RNO-5610787
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Golgi Apparatus
Cell Projection
Cilium
Cytoplasm
Alternative Antibody Names Anti-Adenylate Cyclase Type 3 antibody
Anti-Atp Pyrophosphate-Lyase 3 antibody
Anti-Adenylate Cyclase Type Iii antibody
Anti-Ac-Iii antibody
Anti-Adenylate Cyclase - Olfactive Type antibody
Anti-Adenylyl Cyclase 3 antibody
Anti-Ac3 antibody
Anti-Adcy3 antibody

Information sourced from Uniprot.org

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