| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ADAMTSL4 (795-1074) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ADAMTSL4 |
| Gene ID: |
54507 |
| Uniprot ID: |
ATL4_HUMAN |
| Immunogen Region: |
795-1074 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 795-1074 of human ADAMTSL4 (NP_061905.2). |
| Immunogen Sequence: |
CSVRCGRGQRSRQVRCVGNN GDEVSEQECASGPPQPPSRE ACDMGPCTTAWFHSDWSSKC SAECGTGIQRRSVVCLGSGA ALGPGQGEAGAGTGQSCPTG SRPPDMRACSLGPCERTWRW YTGPWGECSSECGSGTQRRD IICVSKLGTEFNVTSPSNCS HLPRPPALQPCQGQACQDRW FSTPWSPCSRSCQGGTQTRE VQCLSTNQTLSTRCPPQLRP SRKRPCNSQPCSQRPDDQC |
| Tissue Specificity | Expressed in colon, heart, leukocyte, liver, lung, skeletal muscle, spleen, testis and placenta. Weaker expression in bone marrow, brain tissue, kidney and pancreas. Expression studies in fetal tissues reveal strong expression in heart, kidney, liver, lung and skeletal muscle, but weaker expression in fetal brain and skin. |
| Post Translational Modifications | N-glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs. N- and C-glycosylations can also facilitate secretion. |
| Function | Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis. |
| Protein Name | Adamts-Like Protein 4Adamtsl-4Thrombospondin Repeat-Containing Protein 1 |
| Database Links | Reactome: R-HSA-5083635Reactome: R-HSA-5173214 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixColocalizes With Fmn1 Microfibrils In The Eye Ecm |
| Alternative Antibody Names | Anti-Adamts-Like Protein 4 antibodyAnti-Adamtsl-4 antibodyAnti-Thrombospondin Repeat-Containing Protein 1 antibodyAnti-ADAMTSL4 antibodyAnti-TSRC1 antibodyAnti-PP1396 antibodyAnti-UNQ2803 antibodyAnti-PRO34012 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
