| Tissue Specificity | Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart. |
| Post Translational Modifications | Proteolytically cleaved in the trans-Golgi network before it reaches the plasma membrane to generate a mature protein. The removal of the pro-domain occurs via cleavage at two different sites. Processed most likely by a pro-protein convertase such as furin, at the boundary between the pro-domain and the catalytic domain. An additional upstream cleavage pro-protein convertase site (Arg-56/Glu-57) has an important role in the activation of ADAM9. Phosphorylation is induced in vitro by phorbol-12-myristate-13-acetate (PMA). |
| Function | Metalloprotease that cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins. Isoform 2: May act as alpha-secretase for amyloid precursor protein (APP). |
| Protein Name | Disintegrin And Metalloproteinase Domain-Containing Protein 9Adam 9Cellular Disintegrin-Related ProteinMeltrin-GammaMetalloprotease/Disintegrin/Cysteine-Rich Protein 9Myeloma Cell Metalloproteinase |
| Database Links | Reactome: R-HSA-1442490 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Secreted |
| Alternative Antibody Names | Anti-Disintegrin And Metalloproteinase Domain-Containing Protein 9 antibodyAnti-Adam 9 antibodyAnti-Cellular Disintegrin-Related Protein antibodyAnti-Meltrin-Gamma antibodyAnti-Metalloprotease/Disintegrin/Cysteine-Rich Protein 9 antibodyAnti-Myeloma Cell Metalloproteinase antibodyAnti-ADAM9 antibodyAnti-KIAA0021 antibodyAnti-MCMP antibodyAnti-MDC9 antibodyAnti-MLTNG antibody |
Information sourced from Uniprot.org
