| Function | Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism. Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate. Also catalyzes the activation of lipoate to lipoyl-nucleoside monophosphate. Activates lipoate with GTP at a 1000-fold higher rate than with ATP and activates both (R)- and (S)-lipoate to the respective lipoyl-GMP, with a preference for (R)-lipoate. |
| Protein Name | Acyl-Coenzyme A Synthetase Acsm1 - MitochondrialAcyl-Coa Synthetase Medium-Chain Family Member 1Benzoate--Coa LigaseButyrate--Coa Ligase 1Butyryl-Coenzyme A Synthetase 1Lipoate-Activating EnzymeMiddle-Chain Acyl-Coa Synthetase 1Xenobiotic/Medium-Chain Fatty Acid-Coa Ligase Hxm-B |
| Database Links | Reactome: R-HSA-177135Reactome: R-HSA-177162 |
| Cellular Localisation | Mitochondrion MatrixMitochondrion |
| Alternative Antibody Names | Anti-Acyl-Coenzyme A Synthetase Acsm1 - Mitochondrial antibodyAnti-Acyl-Coa Synthetase Medium-Chain Family Member 1 antibodyAnti-Benzoate--Coa Ligase antibodyAnti-Butyrate--Coa Ligase 1 antibodyAnti-Butyryl-Coenzyme A Synthetase 1 antibodyAnti-Lipoate-Activating Enzyme antibodyAnti-Middle-Chain Acyl-Coa Synthetase 1 antibodyAnti-Xenobiotic/Medium-Chain Fatty Acid-Coa Ligase Hxm-B antibodyAnti-ACSM1 antibodyAnti-BUCS1 antibodyAnti-LAE antibodyAnti-MACS1 antibody |
Information sourced from Uniprot.org
