| Post Translational Modifications | Acetylation at Lys-318 and Lys-322 in proximity of the cofactor-binding sites strongly reduces catalytic activity. These sites are deacetylated by SIRT3. |
| Function | Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, long-chain specific acyl-CoA dehydrogenase can act on saturated and unsaturated acyl-CoAs with 6 to 24 carbons with a preference for 8 to 18 carbons long primary chains. |
| Protein Name | Long-Chain Specific Acyl-Coa Dehydrogenase - MitochondrialLcad |
| Database Links | Reactome: R-HSA-77285Reactome: R-HSA-77288Reactome: R-HSA-77310 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Long-Chain Specific Acyl-Coa Dehydrogenase - Mitochondrial antibodyAnti-Lcad antibodyAnti-ACADL antibody |
Information sourced from Uniprot.org
