| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IF/ICC:1:50-1:100 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ABCD2 |
| Gene ID: | 225 |
| Uniprot ID: | ABCD2_HUMAN |
| Immunogen Region: | 420-500 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 420-500 of human ABCD2 (NP_005155.1). |
| Immunogen Sequence: | TARVYNMFWVFDEVKRGIYK RTAVIQESESHSKNGAKVEL PLSDTLAIKGKVIDVDHGII CENVPIITPAGEVVASRLNF K |
| Tissue Specificity | Predominantly expressed in brain and heart. |
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen. Like ABCD1 seems to have fatty acyl-CoA thioesterase (ACOT) and ATPase activities, according to this model, VLCFA-CoA as free VLCFA is transpoted in an ATP-dependent manner into peroxisomes after the hydrolysis of VLCFA-CoA mediated by the ACOT activity of ABCD2 (Probable). Shows overlapping substrate specificities with ABCD1 toward saturated fatty acids (FA) and monounsaturated FA (MUFA) but has a distinct substrate preference for shorter VLCFA (C22:0) and polyunsaturated fatty acid (PUFA) such as C22:6-CoA and C24:6-CoA (in vitro). Thus, may play a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation. |
| Protein Name | Atp-Binding Cassette Sub-Family D Member 2 Adrenoleukodystrophy-Like 1 Adrenoleukodystrophy-Related Protein Haldr |
| Database Links | Reactome: R-HSA-1369062 Reactome: R-HSA-9603798 |
| Cellular Localisation | Peroxisome Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family D Member 2 antibody Anti-Adrenoleukodystrophy-Like 1 antibody Anti-Adrenoleukodystrophy-Related Protein antibody Anti-Haldr antibody Anti-ABCD2 antibody Anti-ALD1 antibody Anti-ALDL1 antibody Anti-ALDR antibody Anti-ALDRP antibody |
Information sourced from Uniprot.org