Anti-ABCB11 antibody (STJ190611)

SKU:
STJ190611

Current Stock:
Host: Rabbit
Applications: WB, ELISA
Reactivity: Human, Rat, Mouse
Note: FOR RESEARCH USE ONLY (RUO).
Short Description: Rabbit polyclonal antibody anti-Bile Salt Export Pump is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS, 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit anti-serum by affinity-chromatography.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ABCB11
Gene ID: 8647
Uniprot ID: ABCBB_HUMAN
Specificity: ABCB11 polyclonal antibody (Bile Salt Export Pump) binds to endogenous Bile Salt Export Pump.
Immunogen: Synthesized peptide derived from part region of human protein
Post Translational Modifications N-glycosylated. Ubiquitinated.short-chain ubiquitination regulates cell-Surface expression of ABCB11.
Function Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts. Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion.
Protein Name Bile Salt Export Pump
Atp-Binding Cassette Sub-Family B Member 11
Database Links Reactome: R-HSA-159418
Reactome: R-HSA-193368
Reactome: R-HSA-5678520
Cellular Localisation Apical Cell Membrane
Multi-Pass Membrane Protein
Recycling Endosome Membrane
Endosome
Cell Membrane
Internalized At The Canalicular Membrane Through Interaction With The Adapter Protein Complex 2 (Ap-2)
At Steady State
Localizes In The Canalicular Membrane But Is Also Present In Recycling Endosomes
Abcb11 Constantly And Rapidly Exchanges Between The Two Sites Through Tubulo-Vesicles Carriers That Move Along Microtubules
Microtubule-Dependent Trafficking Of Abcb11 Is Enhanced By Taurocholate And Camp And Regulated By Stk11 Through A Pka-Mediated Pathway
Trafficking Of Newly Synthesized Abcb11 Through Endosomal Compartment To The Bile Canalicular Membrane Is Accelerated By Camp But Not By Taurocholate
Cell Membrane Expression Is Up-Regulated By Short- And Medium-Chain Fatty Acids
Alternative Antibody Names Anti-Bile Salt Export Pump antibody
Anti-Atp-Binding Cassette Sub-Family B Member 11 antibody
Anti-ABCB11 antibody
Anti-BSEP antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance