Anti-ABCB11 antibody (STJ190611)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Bile salt export pump for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ABCB11 |
| Gene ID | 8647 |
| Uniprot ID | ABCBB_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | ABCBB Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | N-glycosylated. Ubiquitinated.short-chain ubiquitination regulates cell-Surface expression of ABCB11. |
| Function | Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts. Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion. |
| Protein Name | Bile Salt Export PumpAtp-Binding Cassette Sub-Family B Member 11 |
| Database Links | Reactome: R-HSA-159418Reactome: R-HSA-193368Reactome: R-HSA-5678520 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinRecycling Endosome MembraneEndosomeCell MembraneInternalized At The Canalicular Membrane Through Interaction With The Adapter Protein Complex 2 (Ap-2)At Steady StateLocalizes In The Canalicular Membrane But Is Also Present In Recycling EndosomesAbcb11 Constantly And Rapidly Exchanges Between The Two Sites Through Tubulo-Vesicles Carriers That Move Along MicrotubulesMicrotubule-Dependent Trafficking Of Abcb11 Is Enhanced By Taurocholate And Camp And Regulated By Stk11 Through A Pka-Mediated PathwayTrafficking Of Newly Synthesized Abcb11 Through Endosomal Compartment To The Bile Canalicular Membrane Is Accelerated By Camp But Not By TaurocholateCell Membrane Expression Is Up-Regulated By Short- And Medium-Chain Fatty Acids |
| Alternative Antibody Names | Anti-Bile Salt Export Pump antibodyAnti-Atp-Binding Cassette Sub-Family B Member 11 antibodyAnti-ABCB11 antibodyAnti-BSEP antibody |
Information sourced from Uniprot.org