| Tissue Specificity | Ubiquitous. Highly expressed in bone marrow, expressed at intermediate to high levels in skeletal muscle, small intestine, thyroid, heart, brain, placenta, liver, pancreas, prostate, testis, ovary, leukocyte, stomach, spinal cord, lymph node, trachea and adrenal gland, and low levels are found in lung, kidney, spleen, thymus and colon. |
| Function | Catalyzes the export of an unknown physiological substrate from the mitochondrial matrix to the cytosol in an ATP-dependent manner. May also transport the heme analog Zn (II) mesoporphyrin (ZnMP) in an ATP dependent manner but can't export the heme precursor 5-aminolevulinic acid (ALA) from mitochondria. Plays a role in the early step of the heme biosynthetic process during insertion of iron into protoporphyrin IX (PPIX). In turn participates in hemoglobin synthesis and also protects against oxidative stress. In addition may be involved in mitochondrial unfolded protein response (UPRmt) signaling pathway, although ABCB10 probably does not participate in peptide export from mitochondria. |
| Protein Name | Atp-Binding Cassette Sub-Family B Member 10 - MitochondrialAbc-Mitochondrial Erythroid ProteinAbc-Me ProteinAtp-Binding Cassette Transporter 10Abc Transporter 10 ProteinMitochondrial Atp-Binding Cassette 2M-Abc2 |
| Database Links | Reactome: R-HSA-1369007 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family B Member 10 - Mitochondrial antibodyAnti-Abc-Mitochondrial Erythroid Protein antibodyAnti-Abc-Me Protein antibodyAnti-Atp-Binding Cassette Transporter 10 antibodyAnti-Abc Transporter 10 Protein antibodyAnti-Mitochondrial Atp-Binding Cassette 2 antibodyAnti-M-Abc2 antibodyAnti-ABCB10 antibody |
Information sourced from Uniprot.org
