| Post Translational Modifications | N-glycosylated. |
| Function | Probable ATP-binding cassette (ABC) transporter that plays a role in lipid homeostasis and macrophage-mediated phagocytosis. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocyte differentiation. Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation. Plays a role in phagocytosis of apoptotic cells by macrophages. Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7. Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages. Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing. |
| Protein Name | Atp-Binding Cassette Sub-Family A Member 7 |
| Database Links | Reactome: R-MMU-1369062 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembraneEarly Endosome MembraneCytoplasmCell ProjectionRuffle MembranePhagocytic CupLocalizes To Cell Membrane Ruffles And Phagocytic Cups Of Macrophages Stimulated With C1q Or Apoptotic CellsLocalizes To The Cytoplasm Of Resting MacrophagesProbably In Golgi And EndosomesLocalizes To The Apical Brush Border Of Cells In The Proximal Tubules Of Kidney (Probable) |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family A Member 7 antibodyAnti-Abca7 antibody |
Information sourced from Uniprot.org
