| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | <0.01 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: | Measured in a cell proliferation assay using M07e human megakaryocytic leukemic cells. The ED50 for this effect is 0.26-1.02 ng/mL, corresponding to a specific activity of 9.8×105~3.8×106 units/mg. |
| Gene Symbol: | Thpo |
| Gene ID: | 81811 |
| Uniprot ID: | TPO_RAT |
| Immunogen Region: | Ser22-Ser326 |
| Immunogen: | Recombinant Rat THPO/TPO/Thrombopoietin Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser22-Ser326) of Rat THPO/TPO/Thrombopoietin (Accession #NP_112395.1) fused with a His tag at the C-terminus |
| Immunogen Sequence: | QGCPTLAGILDINFLINKMQ EDPASKCHCSANVTSCLCLG IPSDNCTRPCFSERLSQMTN TTMQTRYPLIFSRVKKSVEV LKNNKCPYFSCEQPCNQTTA GNALTFLKSLLEIFQKEKMR GMRGKI |
| Function | Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. |
| Protein Name | Thrombopoietin |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Thrombopoietin proteinThpo protein |
Information sourced from Uniprot.org