| Tissue Specificity | Expressed throughout the gastrointestinal tract with highest levels in the duodenum and jejunum. Low levels in spinal cord, hypothalamus, and stomach. Neuromedin-U-23: Expressed in the small intestine and the pituitary gland (at protein level). Neuromedin precursor-related peptides: Expressed in pituitary gland and small intestine (at protein level). |
| Post Translational Modifications | |
| Function | Neuromedin-U-23: Ligand for receptors NMUR1 and NMUR2. Receptor-binding is very tight if not irreversible and triggers an increase in the cytosolic Ca(2+) concentration. Stimulates muscle contractions of specific regions of the gastrointestinal tract. In rat, NMU stimulates contractions of stomach circular muscle. Neuromedin precursor-related peptide 33: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release although its potency is much lower than that of neuromedin precursor-related peptide 36. Neuromedin precursor-related peptide 36: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system. |
| Protein Name | Neuromedin-U Cleaved Into - Neuromedin Precursor-Related Peptide 36Nurp36 - Neuromedin Precursor-Related Peptide 33Nurp33 - Neuromedin-U-23Nmu-23 |
| Database Links | Reactome: R-RNO-375276Reactome: -RNO-416476Reactome: -RNO-418594 |
| Cellular Localisation | Neuromedin-U-23: Secreted |
| Alternative ELISA Names | Neuromedin-U Cleaved Into - Neuromedin Precursor-Related Peptide 36 ELISA kitNurp36 - Neuromedin Precursor-Related Peptide 33 ELISA kitNurp33 - Neuromedin-U-23 ELISA kitNmu-23 ELISA kitNmu ELISA kit |
| output | |
Information sourced from Uniprot.org
