Rat NHE3 (Sodium/Hydrogen Exchanger 3) Sandwich ELISA Kit Ready-To-Use Kit (STJE0017356)

Rat NHE3 (Sodium/Hydrogen Exchanger 3) Sandwich ELISA Kit Ready-To-Use Kit (STJE0017356)

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STJE0017356
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Applications: ELISA
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.115ng/mL
Detection Limit: 0.312-20ng/mL
Short Description : This NHE3 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat tissue homogenates, cell lysates or other biological fluids..
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Slc9a3
Gene ID: 24784
Uniprot ID: SL9A3_RAT
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Most abundant in colon and small intestine, followed by kidney and stomach. In kidney, expressed in proximal tubules and outer medulla (at protein level).
Post Translational Modifications Phosphorylated by PRKACA at Ser-552 and Ser-605, which inhibits activity. Phosphorylation of Ser-605 is essential for cAMP-mediated inhibition of SLC9A3. Phosphorylation at Ser-661 by SGK1 is associated with increased abundance at the cell membrane. Phosphorylation at Ser-716 by CSNK2A1 regulates SLC9A3 activity through the formation of multiple signaling complexes.
Function Plasma membrane Na(+)/H(+) antiporter. Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, playing a key role in salt and fluid absorption and pH homeostasis. Major apical Na(+)/H(+) exchanger in kidney and intestine playing an important role in renal and intestine Na(+) absorption and blood pressure regulation.
Protein Name Sodium/Hydrogen Exchanger 3
Na(+/H(+ Exchanger 3
Nhe-3
Solute Carrier Family 9 Member 3
Database Links Reactome: R-RNO-425986
Cellular Localisation Apical Cell Membrane
Multi-Pass Membrane Protein
Cell Membrane
Recycling Endosome Membrane
Early Endosome Membrane
In Intestinal Epithelial Cells
Localizes To The Ileal Brush Border
Angiotensin-2 Enhances Apical Expression
Translocates Between Intracellular Compartments And The Plasma Membrane Via A Clathrin-Mediated Pathway
Alternative ELISA Names Sodium/Hydrogen Exchanger 3 ELISA kit
Na(+/H(+ Exchanger 3 ELISA kit
Nhe-3 ELISA kit
Solute Carrier Family 9 Member 3 ELISA kit
Slc9a3 ELISA kit
Nhe3 ELISA kit
output

Information sourced from Uniprot.org

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