Rat E-Cad (Cadherin-1) Antibody Pair (STJAP00346)

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STJAP00346-50
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Host: Rabbit/Rabbit
Applications: ELISA
Reactivity: Rat
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description : This E-Cad antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA.
Clonality : Polyclonal/Polyclonal
Conjugation: Unconjugated/Biotin
Formulation: Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Purification: Capture Purification: Protein A & Antigen Affinity.
Detection Purification: Protein A & Antigen Affinity.
Concentration: 0.5 mg/mL
Storage Instruction: Store at-20°C for long term, and avoid freeze-thaw cycles.
Gene Symbol: Cdh1
Gene ID: 83502
Uniprot ID: CADH1_RAT
Immunogen: Capture immunogen: Recombinant Rat E-Cad protein.
Detection Immunogen: Recombinant Rat E-Cad protein.
Function Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells.cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Promotes organization of radial actin fiber structure and cellular response to contractile forces, via its interaction with AMOTL2 which facilitates anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.
Protein Name Cadherin-1
Epithelial Cadherin
E-Cadherin
Uvomorulin
Cd Antigen Cd324 Cleaved Into - E-Cad/Ctf1 - E-Cad/Ctf2 - E-Cad/Ctf3
Database Links Reactome: R-RNO-1474228
Reactome: -RNO-216083
Reactome: -RNO-351906
Reactome: -RNO-418990
Cellular Localisation Cell Junction
Adherens Junction
Cell Membrane
Single-Pass Type I Membrane Protein
Endosome
Golgi Apparatus
Trans-Golgi Network
Cytoplasm
Desmosome
Colocalizes With Dlgap5 At Sites Of Cell-Cell Contact In Intestinal Epithelial Cells
Anchored To Actin Microfilaments Through Association With Alpha-
Beta- And Gamma-Catenin
Sequential Proteolysis Induced By Apoptosis Or Calcium Influx
Results In Translocation From Sites Of Cell-Cell Contact To The Cytoplasm
Colocalizes With Rab11a Endosomes During Its Transport From The Golgi Apparatus To The Plasma Membrane
Recruited To Desmosomes At The Initial Assembly Phase And Also Accumulates Progressively At Mature Desmosome Cell-Cell Junctions
Localizes To Cell-Cell Contacts As Keratinocyte Differentiation Progresses
Alternative Antibody Pair Names Cadherin-1 antibody pair
Epithelial Cadherin antibody pair
E-Cadherin antibody pair
Uvomorulin antibody pair
Cd Antigen Cd324 Cleaved Into - E-Cad/Ctf1 - E-Cad/Ctf2 - E-Cad/Ctf3 antibody pair
Cdh1 antibody pair

Information sourced from Uniprot.org

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