| Tissue Specificity | |
| Post Translational Modifications | |
| Function | The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Uses ATP as an energy source to pump H(+) ions to the gastric lumen while transporting K(+) ion from the lumen into the cell. Remarkably generates a million-fold proton gradient across the gastric parietal cell membrane, acidifying the gastric juice down to pH 1. Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). The release of the H(+) ion in the stomach lumen is followed by binding of K(+) ion converting the pump conformation back to the E1 state. |
| Protein Name | Potassium-Transporting Atpase Alpha Chain 1Gastric H(+/K(+ Atpase Subunit AlphaProton Pump |
| Database Links | |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinLocalized In The Apical Canalicular Membrane Of Parietal Cells |
| Alternative ELISA Names | Potassium-Transporting Atpase Alpha Chain 1 ELISA kitGastric H(+/K(+ Atpase Subunit Alpha ELISA kitProton Pump ELISA kitAtp4a ELISA kitHka ELISA kit |
| output | |
Information sourced from Uniprot.org
