| Function | Phosphatidylserine receptor that plays different role in immune response including phagocytosis of apoptotic cells and T-cell regulation. Controls T-cell activation in a bimodal fashion, decreasing the activation of naive T-cells by inducing cell cycle arrest, while increasing proliferation of activated T-cells by activating AKT1 and ERK1/2 phosphorylations and subsequent signaling pathways. Also plays a role in efferocytosis which is the process by which apoptotic cells are removed by phagocytic cells. Mechanistically, promotes the engulfment of apoptotic cells or exogenous particles by securing them to phagocytes through direct binding to phosphatidylserine present on apoptotic cells, while other engulfment receptors such as MERTK efficiently recognize apoptotic cells and mediate their ingestion. Additionally, promotes autophagy process by suppressing NLRP3 inflammasome activity via activation of STK11/PRKAA1 pathway in a phosphatidylserine-dependent mechanism. |
| Protein Name | T-Cell Immunoglobulin And Mucin Domain-Containing Protein 4Timd-4Spleen - Mucin-Containing - Knockout Of Lymphotoxin ProteinSmucklerT-Cell Immunoglobulin Mucin Receptor 4Tim-4T-Cell Membrane Protein 4 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | T-Cell Immunoglobulin And Mucin Domain-Containing Protein 4 proteinTimd-4 proteinSpleen - Mucin-Containing - Knockout Of Lymphotoxin Protein proteinSmuckler proteinT-Cell Immunoglobulin Mucin Receptor 4 proteinTim-4 proteinT-Cell Membrane Protein 4 proteinTimd4 proteinTim4 protein |
Information sourced from Uniprot.org
