| Tissue Specificity | Expressed primarily in liver, ovary and adrenal gland, and, at lower levels in other non-placental steroidogenic tissues, including adipose tissue, mammary gland and testis (at protein level). Isoform 2 is expressed at lower levels than isoform 1 in liver, testis and adrenal gland. At the mRNA, but not at the protein level, isoform 2 is the predominant isoform in testis (80%). |
| Post Translational Modifications | N-glycosylated. The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds. |
| Function | Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Both isoform 1 and isoform 2 act as receptors for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. |
| Protein Name | Scavenger Receptor Class B Member 1Srb1Sr-Bi |
| Database Links | Reactome: R-MMU-3000471Reactome: -MMU-8964011 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinMembraneCaveolaPredominantly Localized To Cholesterol And Sphingomyelin-Enriched Domains Within The Plasma MembraneCalled CaveolaeIsoform 1: Cell MembraneIsoform 2: Cell Membrane |
| Alternative Protein Names | Scavenger Receptor Class B Member 1 proteinSrb1 proteinSr-Bi proteinScarb1 proteinSrb1 protein |
Information sourced from Uniprot.org
