| Tissue Specificity | Expressed in white and brown adipose tissues. |
| Post Translational Modifications | |
| Function | Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. |
| Protein Name | Serine Palmitoyltransferase 3Long Chain Base Biosynthesis Protein 2bLcb2bLong Chain Base Biosynthesis Protein 3Lcb 3Serine-Palmityl-Coa Transferase 3Spt 3 |
| Database Links | Reactome: R-MMU-1660661 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative ELISA Names | Serine Palmitoyltransferase 3 ELISA kitLong Chain Base Biosynthesis Protein 2b ELISA kitLcb2b ELISA kitLong Chain Base Biosynthesis Protein 3 ELISA kitLcb 3 ELISA kitSerine-Palmityl-Coa Transferase 3 ELISA kitSpt 3 ELISA kitSptlc3 ELISA kitSptlc2l ELISA kit |
| output | |
Information sourced from Uniprot.org
