Tissue Specificity | Ubiquitously expressed. |
Post Translational Modifications | Could homodimerize through the formation of dityrosine bonds upon oxidative stress. |
Function | Together with SLC30A6 forms a functional proton-coupled zinc ion antiporter mediating zinc entry into the lumen of organelles along the secretory pathway. By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis. Through the transport of zinc into secretory granules of pancreatic beta-cells, plays an important role in the storage and secretion of insulin. |
Protein Name | Proton-Coupled Zinc Antiporter Slc30a5Solute Carrier Family 30 Member 5Zinc Transporter 5Znt-5 |
Database Links | Reactome: R-MMU-264876Reactome: -MMU-435368 |
Cellular Localisation | Golgi ApparatusGolgi Stack MembraneMulti-Pass Membrane ProteinCytoplasmic VesicleCopii-Coated Vesicle MembraneSecretory Vesicle MembraneTrans-Golgi Network MembraneEnriched In Early Compartments Of The Secretory Pathway Including Copii-Coated Vesicles And The Golgi Cis Cisterna |
Alternative ELISA Names | Proton-Coupled Zinc Antiporter Slc30a5 ELISA kitSolute Carrier Family 30 Member 5 ELISA kitZinc Transporter 5 ELISA kitZnt-5 ELISA kitSlc30a5 ELISA kitZnt5 ELISA kit |
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Information sourced from Uniprot.org