| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Mouse RANBP2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | Ranbp2 |
| Gene ID: | 19386 |
| Uniprot ID: | RBP2_MOUSE |
| Immunogen Region: | Tyr1840-Ala2000 |
| Immunogen: | Mus musculus (Mouse) |
| Function | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single-stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Inhibits EIF4E-dependent mRNA export. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. |
| Protein Name | E3 Sumo-Protein Ligase Ranbp2Ran-Binding Protein 2Ranbp2 |
| Database Links | Reactome: R-MMU-141444Reactome: -MMU-159227Reactome: -MMU-159230Reactome: -MMU-159231Reactome: -MMU-159236Reactome: -MMU-170822Reactome: -MMU-191859Reactome: -MMU-2467813Reactome: -MMU-2500257Reactome: -MMU-3108214Reactome: -MMU-3232142Reactome: -MMU-3301854Reactome: -MMU-3371453Reactome: -MMU-4085377Reactome: -MMU-4551638Reactome: -MMU-4570464Reactome: -MMU-4615885Reactome: -MMU-5578749Reactome: -MMU-5663220Reactome: -MMU-68877Reactome: -MMU-9648025 |
| Cellular Localisation | NucleusNucleus MembraneNuclear Pore ComplexNucleus EnvelopeDetected In Diffuse And Discrete Intranuclear FociCytoplasmic Filaments |
| Alternative Protein Names | E3 Sumo-Protein Ligase Ranbp2 proteinRan-Binding Protein 2 proteinRanbp2 proteinRanbp2 protein |
Information sourced from Uniprot.org