| Tissue Specificity | Expressed in all tissues examined, with highest levels in brain and testes and lowest levels in lung. |
| Post Translational Modifications | Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors. Phosphorylated on tyrosine residues by EPHB2 and on serine or threonine residues by PKC. Palmitoylation on Cys-414 is essential for long-term synaptic depression (LTD). |
| Function | Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex.the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function. |
| Protein Name | Prkca-Binding ProteinProtein Interacting With C Kinase 1Protein Kinase C-Alpha-Binding Protein |
| Database Links | |
| Cellular Localisation | CytoplasmPerinuclear RegionMembranePeripheral Membrane ProteinLipid-AnchorPostsynaptic DensitySynapseSynaptosomeCytoskeletonAlso Membrane-AssociatedPresent At Excitatory Synapses |
| Alternative ELISA Names | Prkca-Binding Protein ELISA kitProtein Interacting With C Kinase 1 ELISA kitProtein Kinase C-Alpha-Binding Protein ELISA kitPick1 ELISA kitPrkcabp ELISA kit |
| output | |
Information sourced from Uniprot.org
