Tissue Specificity | HCNP is expressed in brain. Increased expression in aged senescence-accelerated mice. |
Post Translational Modifications | |
Function | Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase. Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor. |
Protein Name | Phosphatidylethanolamine-Binding Protein 1Pebp-1Hcnppp Cleaved Into - Hippocampal Cholinergic Neurostimulating PeptideHcnp |
Database Links | Reactome: R-MMU-5674135Reactome: -MMU-5675221 |
Cellular Localisation | Cytoplasm |
Alternative ELISA Names | Phosphatidylethanolamine-Binding Protein 1 ELISA kitPebp-1 ELISA kitHcnppp Cleaved Into - Hippocampal Cholinergic Neurostimulating Peptide ELISA kitHcnp ELISA kitPebp1 ELISA kitPbp ELISA kitPebp ELISA kit |
output | |
Information sourced from Uniprot.org