Function | Acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils. Plays an important role in mediating peripheral nerve injury-induced neuropathic pain. Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B. |
Protein Name | C-C Motif Chemokine 2Monocyte Chemoattractant Protein 1Monocyte Chemotactic Protein 1Mcp-1Platelet-Derived Growth Factor-Inducible Protein JeSmall-Inducible Cytokine A2 |
Cellular Localisation | Secreted |
Alternative Antibody Pair Names | C-C Motif Chemokine 2 antibody pairMonocyte Chemoattractant Protein 1 antibody pairMonocyte Chemotactic Protein 1 antibody pairMcp-1 antibody pairPlatelet-Derived Growth Factor-Inducible Protein Je antibody pairSmall-Inducible Cytokine A2 antibody pairCcl2 antibody pairJe antibody pairMcp1 antibody pairScya2 antibody pair |
Information sourced from Uniprot.org