| Host: |
HEK293 cells |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Mouse IL-33-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Il33 |
| Gene ID: |
77125 |
| Uniprot ID: |
IL33_MOUSE |
| Immunogen Region: |
Ser109-Ile266 |
| Immunogen: |
Recombinant Mouse IL-33 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser109-Ile266) of mouse IL33 (Accession #NP_598536.2) fused with and a 6×His tag at the C-terminus. |
| Function | Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as an enhancer of polarization of alternatively activated macrophages. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury. Induces rapid UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages. In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or pro-inflammatory activation. |
| Protein Name | Interleukin-33Il-33 Cleaved Into - Interleukin-33(102-266 - Interleukin-33(109-266 |
| Database Links | Reactome: R-MMU-1257604Reactome: -MMU-5689880Reactome: -MMU-6811558Reactome: -MMU-9014843 |
| Cellular Localisation | NucleusChromosomeCytoplasmCytoplasmic VesicleSecretory VesicleSecretedSecreted And Released In The Extracellular Milieu By Passing Through The Gasdermin-D (Gsdmd) Pore Following Cleavage By Cela1Associates With Heterochromatin And Mitotic ChromosomesThe Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion(Microbial Infection) Upon Infection With HPolygyrusTethered To The Nucleus By The HPolygyrus Parasitic Protein Ari |
| Alternative Protein Names | Interleukin-33 proteinIl-33 Cleaved Into - Interleukin-33(102-266 - Interleukin-33(109-266 proteinIl33 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
