| Post Translational Modifications | N-glycosylated. Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain. Cleavage is probably effected by a metalloprotease. |
| Function | Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis. |
| Protein Name | Leucine-Rich Repeat Transmembrane Protein Flrt2Fibronectin Leucine Rich Transmembrane Protein 2 |
| Database Links | Reactome: R-MMU-5654687 |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinEndoplasmic Reticulum MembraneCell JunctionFocal AdhesionSecretedExtracellular SpaceExtracellular MatrixSynapseSynaptosomeMicrosome MembraneProteolytic Cleavage Gives Rise To A Shedded Ectodomain |
| Alternative Protein Names | Leucine-Rich Repeat Transmembrane Protein Flrt2 proteinFibronectin Leucine Rich Transmembrane Protein 2 proteinFlrt2 proteinKiaa0405 protein |
Information sourced from Uniprot.org
