Name: Mouse Ephrin-B2/EFNB2 protein (Recombinant) (C-His) (STJP001463)
SKU: STJP001463
Availability: InStock

General Information
Product Properties
Target Information
Additional Info
Product Review

Host:	HEK293 cells
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Formulation:	Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method:	< 0.1 EU/Mu g of the protein by LAL method.
Immunoreactivity:	Measured by its binding ability in a functional ELISA. Immobilized Mouse EFNB2 at 1 Mu g/mL (100 Mu L/well) can bind Mouse EPHB2 with a linear range of 0.01-1.3 ng/mL.

Gene Symbol:	Efnb2
Gene ID:	13642
Uniprot ID:	EFNB2_MOUSE
Immunogen:	Recombinant Mouse Ephrin-B2/EFNB2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Arg29-Ala232) of mouse Ephrin-B2/EFNB2 (Accession #NP_034241.2) fused with a 6×His tag at the C-terminus.
Immunogen Sequence:	RSIVLEPIYWNSSNSKFLPG QGLVLYPQIGDKLDIICPKV DSKTVGQYEYYKVYMVDKDQ ADRCTIKKENTPLLNCARPD QDVKFTIKFQEFSPNLWGLE FQKNKDYYIISTSNGSLEGL DNQEGGVCQTRAMKILMKVG QDASSAGSARNHGPTRRPEL EAGTNGRSSTTSPFVKPNPG SSTDGNSAGHSGNNLLGSEV ALFA

Post Translational Modifications	Inducible phosphorylation of tyrosine residues in the cytoplasmic domain.
Function	Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.
Protein Name	Ephrin-B2 Elf-2 Eph-Related Receptor Tyrosine Kinase Ligand 5 Lerk-5 Htk Ligand Htk-L
Database Links	Reactome: R-MMU-2682334 Reactome: -MMU-3928662 Reactome: -MMU-3928664 Reactome: -MMU-3928665
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Cell Junction Adherens Junction
Alternative Protein Names	Ephrin-B2 protein Elf-2 protein Eph-Related Receptor Tyrosine Kinase Ligand 5 protein Lerk-5 protein Htk Ligand protein Htk-L protein Efnb2 protein Elf2 protein Epl5 protein Eplg5 protein Htkl protein Lerk5 protein

Information sourced from Uniprot.org

Model	Name	Host	Reactivity	Application
STJP002561	Human Ephrin-B2/EFNB2 protein (Recombinant) (C-His) (STJP002561)	HEK293 cells
STJE0008588	Mouse EFNB2 (Ephrin B2) Sandwich ELISA Kit Kit (STJE0008588)		Mouse	ELISA
STJP003024	Mouse Ephrin-B3/EFNB3 protein (Recombinant) (C-His) (STJP003024)	HEK293 cells
STJP001507	Mouse Ephrin-A2/EFNA2 protein (Recombinant) (C-His) (STJP001507)	HEK293 cells
STJE0014966	Mouse EFNB2 (Ephrin B2) Sandwich ELISA Kit Ready-To-Use Kit (STJE0014966)		Mouse	ELISA

Mouse Ephrin-B2/EFNB2 protein (Recombinant) (C-His) (STJP001463)

Related Products