| Tissue Specificity | Expressed in the kidney, liver and intestine, with higher levels in the ileum than in the jejunum. Low levels in the brain. Expressed in colonic epithelium (at protein level). Expressed in the perivenous regions, bile ducts, and gallbladder epithelium (at protein level). |
| Post Translational Modifications | The disulfide bond is necessary for pore formation, but is not required for correct protein trafficking. |
| Function | Forms paracellular channels: polymerizes in tight junction strands with cation- and water-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability. In intestinal epithelium, allows for sodium and water fluxes from the peritoneal side to the lumen of the intestine to regulate nutrient absorption and clear enteric pathogens as part of mucosal immune response. In kidney, allows passive sodium and calcium reabsorption across proximal tubules from the lumen back to the bloodstream. In the hepatobiliary tract, allows paracellular water and cation fluxes in the hepatic perivenous areas and biliary epithelium to generate bile flow and maintain osmotic gradients. |
| Protein Name | Claudin-2 |
| Database Links | |
| Cellular Localisation | Cell JunctionTight JunctionCell MembraneMulti-Pass Membrane Protein |
| Alternative ELISA Names | Claudin-2 ELISA kitCldn2 ELISA kit |
| output | |
Information sourced from Uniprot.org
