Mouse CD5 protein (Recombinant) (C-His) (STJP001495)

SKU:
STJP001495
$131.63 - $393.53
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Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: <0.1 EU/Mu g
Gene Symbol: Cd5
Gene ID: 12507
Uniprot ID: CD5_MOUSE
Immunogen: Recombinant Mouse CD5 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser25-Pro371) of mouse CD5/Lyt1 (Accession #NP_031676.3) fused with a 6×His tag at the C-terminus.
Immunogen Sequence: SGRGGLDIQVMLSGSNSKCQ GQVEIQMENKWKTVCSSSWR LSQDHSKNAQQASAVCKQLR CGDPLALGPFPSLNRPQNQV FCQGSPWSISNCNNTSSQDQ CLPLSLICLEPQRTTPPPTT TPPTTVPEPTAPPRLQLVPG HEGLRCTGVVEFYNGSWGGT ILYKAKDRPLGLGNLICKSL QCGSFLTHLSGTEAAGTPAP AELRDPRPLPIRWEAPNGSC VSLQQCFQKTTAQEGGQAL
Function Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance. Acts by interacting with several ligands expressed on B-cells such as CD5L or CD72 and thereby plays an important role in contact-mediated, T-dependent B-cell activation and in the maintenance of regulatory T and B-cell homeostasis. Functions as a negative regulator of TCR signaling during thymocyte development by associating with several signaling proteins including LCK, CD3Z chain, PI3K or CBL. Mechanistically, co-engagement of CD3 with CD5 enhances phosphorylated CBL recruitment leading to increased VAV1 phosphorylation and degradation. Modulates B-cell biology through ERK1/2 activation in a Ca(2+)-dependent pathway via the non-selective Ca(2+) channel TRPC1, leading to IL-10 production.
Protein Name T-Cell Surface Glycoprotein Cd5
Lymphocyte Antigen 1
Ly-1
Lyt-1
Cd Antigen Cd5
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names T-Cell Surface Glycoprotein Cd5 protein
Lymphocyte Antigen 1 protein
Ly-1 protein
Lyt-1 protein
Cd Antigen Cd5 protein
Cd5 protein
Ly-1 protein

Information sourced from Uniprot.org