| Function | IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), mouse mammary tumor virus (MMTV) and murine leukemia virus (MLV), filoviridae: ebola virus (EBOV), arenaviridae: lassa virus (LASV), and rhabdoviridae: vesicular stomatitis virus (VSV). Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection. Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. |
| Protein Name | Bone Marrow Stromal Antigen 2Bst-2Hm1.24 AntigenCd Antigen Cd317 |
| Database Links | Reactome: R-MMU-6798695 |
| Cellular Localisation | Golgi ApparatusTrans-Golgi NetworkCell MembraneSingle-Pass Type Ii Membrane ProteinLipid-AnchorGpi-AnchorLate EndosomeMembrane RaftCytoplasmApical Cell MembraneShuttles Between The Cell MembraneWhere It Is Present Predominantly In Membrane/Lipid RaftsAnd The Trans-Golgi NetworkForms A Complex With Mmp14 And Localizes To The Cytoplasm |
| Alternative Protein Names | Bone Marrow Stromal Antigen 2 proteinBst-2 proteinHm1.24 Antigen proteinCd Antigen Cd317 proteinBst2 protein |
Information sourced from Uniprot.org
