| Tissue Specificity | Expressed in a wide variety of tissues. |
| Post Translational Modifications | Ubiquitinated on Lys-128 and Lys-190. 'Lys-63'-linked polyubiquitin chains on Lys-128 are removed by USP12. |
| Function | Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. BAX deficiency leads to lymphoid hyperplasia and male sterility, because of the cessation of sperm production. |
| Protein Name | Apoptosis Regulator Bax |
| Database Links | Reactome: R-MMU-111457Reactome: -MMU-114294Reactome: -MMU-5620971Reactome: -MMU-6804114 |
| Cellular Localisation | Isoform Alpha: Mitochondrion Outer MembraneSingle-Pass Membrane ProteinCytoplasmNucleusColocalizes With 14-3-3 Proteins In The CytoplasmUnder Stress ConditionsUndergoes A Conformation Change That Causes Release From Jnk-Phosphorylated 14-3-3 Proteins And Translocation To The Mitochondrion MembraneIsoform Beta: CytoplasmIsoform Gamma: Cytoplasm |
| Alternative ELISA Names | Apoptosis Regulator Bax ELISA kitBax ELISA kit |
| output | |
Information sourced from Uniprot.org
