Human XKR8 protein (Recombinant) (N-His-SUMO) (STJP005999)

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STJP005999
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human XKR8-N-His-SUMO protein was developed from e. coli and has a target region of N-His-SUMO. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: XKR8
Gene ID: 55113
Uniprot ID: XKR8_HUMAN
Immunogen Region: Arg69-Arg158
Immunogen: Homo sapiens (Human)
Function XK-related protein 8, processed form: Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. Required for the clearance of apoptotic cells, such as engulfment of apoptotic germ cells by Sertoli cells, clearance of senescent neutrophils or regulation of bipolar cell numbers in the retina. Has no effect on calcium-induced exposure of phosphatidylserine. Promotes myoblast differentiation and survival. (Microbial infection) Incorporated into Ebola virus-like particles, where its phospholipid scramblase activity is required to promote phosphatidylserine exposure on the surface of viral particles. Externalization of phosphatidylserine on the surface of viral particles is required for uptake by host cells.
Protein Name Xk-Related Protein 8
Hxkr8 Cleaved Into - Xk-Related Protein 8 - Processed Form
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Cytoplasm
Perinuclear Region
Alternative Protein Names Xk-Related Protein 8 protein
Hxkr8 Cleaved Into - Xk-Related Protein 8 - Processed Form protein
XKR8 protein
XRG8 protein

Information sourced from Uniprot.org