Human WDR1 protein (Recombinant) (N-His) (STJP007512)

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STJP007512
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human WDR1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: WDR1
Gene ID: 9948
Uniprot ID: WDR1_HUMAN
Immunogen Region: Met1-Lys317
Immunogen: Homo sapiens (Human)
Function Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Enhances cofilin-mediated actin severing. Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions. Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance. Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP.the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension. Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt.
Protein Name Wd Repeat-Containing Protein 1
Actin-Interacting Protein 1
Aip1
Nori-1
Database Links Reactome: R-HSA-114608
Cellular Localisation Cytoplasm
Cytoskeleton
Cell Projection
Podosome
Cell Junction
Alternative Protein Names Wd Repeat-Containing Protein 1 protein
Actin-Interacting Protein 1 protein
Aip1 protein
Nori-1 protein
WDR1 protein

Information sourced from Uniprot.org

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